PT  - JOURNAL ARTICLE
AU  - LYUBOMIR HARALAMBIEV
AU  - ARNAB BANDYOPHADYAY
AU  - BETTINA SUCHY
AU  - MARTIN WEISS
AU  - AXEL KRAMER
AU  - SANDER BEKESCHUS
AU  - AXEL EKKERNKAMP
AU  - ALEXANDER MUSTEA
AU  - LARS KADERALI
AU  - MATTHIAS B. STOPE
TI  - Determination of Immediate <em>vs.</em> Kinetic Growth Retardation in Physically Plasma-treated Cells by Experimental and Modelling Data
AID  - 10.21873/anticanres.14363
DP  - 2020 Jul 01
TA  - Anticancer Research
PG  - 3743--3749
VI  - 40
IP  - 7
4099  - http://ar.iiarjournals.org/content/40/7/3743.short
4100  - http://ar.iiarjournals.org/content/40/7/3743.full
SO  - Anticancer Res2020 Jul 01; 40
AB  - Background/Aim: The antiproliferative effects of cold atmospheric plasma (CAP) make it a promising application option in oncology. The aim of the present study was to examine whether short-term CAP treatment leads to an initial partial elimination of the treated cells or to long-term impairement and inhibition of cell growth. Materials and Methods: Cells were treated with CAP and biostatistical modelling was used to estimate growth rates over the incubation time. Four cell lines (U2-OS and MNNG osteosarcoma cells, 3T3 fibroblasts, HaCaT keratinocytes) and three CAP sources (MiniJet-R, kINPen MED, Maxium) were used. Results: The antiproliferative efficacy of CAP was due to a significant reduction in cell count during treatment and the long-lasting inhibition of growth rate in the remaining cells, detectable in all cell lines and after treatment using all three CAP devices. Conclusion: Induction of cell death and inhibition of cell growth are part of a general mechanism of biological CAP efficacy. However, data contradict the hypothesis that cancer cells respond more sensitively to CAP treatment compared to non-malignant cells.