TY - JOUR T1 - Analysis of Sciellin (SCEL) as a Candidate Gene in Esophageal Squamous Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 1417 LP - 1420 VL - 24 IS - 3A AU - WINSTON CORONA AU - DEEPA J. KARKERA AU - ROBERT H. PATTERSON AU - NIRMAL SAINI AU - GREGORY D. TRACHIOTIS AU - LOUIS Y. KORMAN AU - BENITA LIU AU - EDMUND P. ALEXANDER AU - ARTURO S. DE LA PENA AU - ALVIN B. MARCELO AU - ROBERT WADLEIGH Y1 - 2004/05/01 UR - http://ar.iiarjournals.org/content/24/3A/1417.abstract N2 - Background: The aim of this study was to investigate whether a candidate gene, Sciellin (SCEL), mapping to the chromosome 13q21-q31 is mutated in esophageal cancer. Materials and Methods: The coding region and intron-exon junctions of SCEL were sequenced in 13 esophageal squamous cell cancers and matching normal esophageal samples to detect mutations. Results: Three single nucleotide polymorphisms were detected in SCEL of which two were silent mutations (L640L and H654H) and one missense mutation (R366K). Conclusion: Single nucleotide polymorphisms were detected in both matching tumor and normal esophageal tissues but no disease-associated mutations suggesting that SCEL is not a major factor in esophageal squamous cell carcinogenesis. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -