PT  - JOURNAL ARTICLE
AU  - WINSTON CORONA
AU  - DEEPA J. KARKERA
AU  - ROBERT H. PATTERSON
AU  - NIRMAL SAINI
AU  - GREGORY D. TRACHIOTIS
AU  - LOUIS Y. KORMAN
AU  - BENITA LIU
AU  - EDMUND P. ALEXANDER
AU  - ARTURO S. DE LA PENA
AU  - ALVIN B. MARCELO
AU  - ROBERT WADLEIGH
TI  - Analysis of Sciellin (SCEL) as a Candidate Gene in Esophageal Squamous Cell Carcinoma
DP  - 2004 May 01
TA  - Anticancer Research
PG  - 1417--1420
VI  - 24
IP  - 3A
4099  - http://ar.iiarjournals.org/content/24/3A/1417.short
4100  - http://ar.iiarjournals.org/content/24/3A/1417.full
SO  - Anticancer Res2004 May 01; 24
AB  - Background: The aim of this study was to investigate whether a candidate gene, Sciellin (SCEL), mapping to the chromosome 13q21-q31 is mutated in esophageal cancer. Materials and Methods: The coding region and intron-exon junctions of SCEL were sequenced in 13 esophageal squamous cell cancers and matching normal esophageal samples to detect mutations. Results: Three single nucleotide polymorphisms were detected in SCEL of which two were silent mutations (L640L and H654H) and one missense mutation (R366K). Conclusion: Single nucleotide polymorphisms were detected in both matching tumor and normal esophageal tissues but no disease-associated mutations suggesting that SCEL is not a major factor in esophageal squamous cell carcinogenesis. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved