PT - JOURNAL ARTICLE AU - YUKIO MAEZAWA AU - TORU AOYAMA AU - MIHWA JU AU - KEISUKE KOMORI AU - KAZUKI KANO AU - SHO SAWAZAKI AU - MASAKATSU NUMATA AU - TSUTOMU HAYASHI AU - TAKANOBU YAMADA AU - HIROSHI TAMAGAWA AU - TSUTOMU SATO AU - TAKASHI OGATA AU - HARUHIKO CHO AU - TAKASHI OSHIMA AU - NORIO YUKAWA AU - TAKAKI YOSHIKAWA AU - MUNETAKA MASUDA AU - YASUSHI RINO TI - The Impact of Severe Infectious Complications on Long-term Prognosis for Gastric Cancer AID - 10.21873/anticanres.14404 DP - 2020 Jul 01 TA - Anticancer Research PG - 4067--4074 VI - 40 IP - 7 4099 - http://ar.iiarjournals.org/content/40/7/4067.short 4100 - http://ar.iiarjournals.org/content/40/7/4067.full SO - Anticancer Res2020 Jul 01; 40 AB - Background: The aim of this study was to evaluate the impact of postoperative infectious complications on long-term outcomes after curative resection of gastric cancer. Patients and Methods: Patients who underwent curative gastrectomy with lymphadenectomy for gastric cancer at Yokohama City University and Kanagawa Cancer Center from January 2000 to August 2015 were retrospectively selected from medical records. Clinicopathological factors between patients with and without infectious complications were compared. Prognostic factors of long-term survival were analyzed by univariate and multivariate Cox proportional hazards analyses. Results: A total of 2,254 patients were eligible for inclusion in the present study. Fifty-eight patients had postoperative infectious complications (IC group); 2,196 had no postoperative infectious complications (NC group). In the IC group, the median age (p=0.031), body mass index (p=0.004), American Society of Anesthesiologists physical status (p=0.006) and percentage of male patients (p<0.001) were higher in comparison to the NC group. The operation time was longer (p<0.001) and the incidence of intestinal-type histology was higher (p=0.017) in the IC group. The 5-year overall survival rates of the IC and NC groups were 59.8% and 83.2%, respectively (p<0.001). Univariate and multivariate analyses demonstrated that postoperative infectious complications were a significant risk factor for poorer overall survival (hazard ratio=2.38; 95% confidence interval=1.47-3.85, p<0.001). Conclusion: Perioperative management is necessary to reduce the incidence of postoperative infectious complications and improve the survival of patients after curative resection of gastric cancer.