RT Journal Article SR Electronic T1 FGD3 Gene as a New Prognostic Factor in Breast Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3645 OP 3649 DO 10.21873/anticanres.14353 VO 40 IS 7 A1 TOMMASO SUSINI A1 IRENE RENDA YR 2020 UL http://ar.iiarjournals.org/content/40/7/3645.abstract AB Despite the establishment of the traditional prognostic factors for breast cancer, patients belonging to the same histological and molecular subgroup often present quite different outcomes. Recently, the introduction of gene expression profiling, assessed by RT-qPCR and microarray DNA analysis, offered a view of the whole cell gene activity and the ability to identify new transcripts that are associated with outcome. This review aimed to gather all recent trials about new breast cancer prognostic factors, focusing on the most promising one, the FGD3 gene, and to discuss the real feasibility of a molecular approach in everyday clinical practice. In conclusion, all literature concerning this subject indicated that expression of the FGD3 gene is a strong marker of good prognosis in breast cancer patients and that immunohistochemistry represents an efficient, inexpensive, reproducible evaluation method, affordable also by small Institutions.