@article {AUTORINO3417, author = {ROSA AUTORINO and SILVIA BISIELLO and BRIGIDA PAPPALARDI and VANESSA PRIVITERA and MILLY BUWENGE and FEDERICA PICCOLO and CARLOTTA MASCIOCCHI and LUCA TAGLIAFERRI and GABRIELLA MACCHIA and CLELIA DELLE CURTI and MARCO LUPPATTELI and ANNAMARIA CERROTTA and ALESSIO GIUSEPPE MORGANTI and VINCENZO VALENTINI and GIANCARLO MATTIUCCI}, title = {Intraluminal Brachytherapy in Unresectable Extrahepatic Biliary Duct Cancer: An Italian Pooled Analysis}, volume = {40}, number = {6}, pages = {3417--3421}, year = {2020}, doi = {10.21873/anticanres.14326}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: To evaluate the outcome of patients with unresectable extrahepatic cholangiocarcinoma (CC) treated with external-beam radiotherapy (EBRT) and concurrent chemotherapy (CT) with or without intraluminal brachytherapy (ILBT) boost or with definitive ILBT. Patients and Methods: A pooled analysis of patients with non-metastatic unresectable CC was performed. They were treated in three different institution with EBRT plus CT with or without an ILBT boost. Some patients received only ILBT with curative dose. Results: Seventy-three patients were included in the analysis. Thirty-nine patients (53\%) received EBRT treatment with ILBT boost (18 patients with CT during EBRT), while 28 patients (38\%) were treated with EBRT (CT in 26 patients) and 6 patients (8.2\%) with definitive ILBT (2 patients with CT). CT was administered including either the use of gemcitabine or 5-fluorouracil. With a median follow-up of 16 month (range=1-94 months), median overall survival (OS) was 16 months. Overall median LC was 16 months and patients who underwent ILBT had a better local control (LC) (p=0.018). Conclusion: The role of ILBT in unresectable CC is not yet supported by robust evidence in the literature. However, within this limit, preliminary results seem to suggest an improved local control in patients treated with ILBT, almost comparable to the ones of standard chemo-radiotherapy (CRT).}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/6/3417}, eprint = {https://ar.iiarjournals.org/content/40/6/3417.full.pdf}, journal = {Anticancer Research} }