RT Journal Article
SR Electronic
T1 Induction Chemotherapy in Hypopharyngeal Cancer: Influence of DNA Repair Gene Polymorphisms
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3277
OP 3285
DO 10.21873/anticanres.14310
VO 40
IS 6
A1 HITOSHI HIRAKAWA
A1 TARO IKEGAMI
A1 SATOE AZECHI
A1 SHINYA AGENA
A1 JIN UEZATO
A1 HIDETOSHI KINJYO
A1 YUKASHI YAMASHITA
A1 ASANORI KIYUNA
A1 KATSUNORI TANAKA
A1 SHUNSUKE KONDO
A1 HIROYUKI MAEDA
A1 MIKIO SUZUKI
A1 AKIRA GANAHA
YR 2020
UL http://ar.iiarjournals.org/content/40/6/3277.abstract
AB Background/Aim: The aim was to clarify whether DNA repair gene polymorphisms can be used to predict response to cisplatin, 5-fluorouracil, and docetaxel (TPF) as induction chemotherapy (ICT) in Japanese patients with hypopharyngeal cancer (HPC). Materials and Methods: DNA repair gene polymorphisms (rs3212986, rs1799793, rs13181, and rs25487) were analyzed in 117 HPC patients and 125 control subjects by PCR-restriction fragment length polymorphism. Forty-one HPC patients who received TPF-based ICT, followed by surgery or chemoradiotherapy/radiotherapy were analyzed for ICT response, laryngeal preservation, and survival outcome. Results: ICT responders (29 cases) had significantly better overall survival than ICT non-responders (12 cases; 86.0% vs. 37.0%, respectively, p<0.01 by log-rank test) and better laryngeal preservation rates. The DNA repair gene polymorphisms were not related to ICT response. Conclusion: ICT is beneficial for chemoselection of HPC patients, but a role for DNA repair gene polymorphisms in ICT response was not confirmed.