TY - JOUR T1 - Induction Chemotherapy in Hypopharyngeal Cancer: Influence of DNA Repair Gene Polymorphisms JF - Anticancer Research JO - Anticancer Res SP - 3277 LP - 3285 DO - 10.21873/anticanres.14310 VL - 40 IS - 6 AU - HITOSHI HIRAKAWA AU - TARO IKEGAMI AU - SATOE AZECHI AU - SHINYA AGENA AU - JIN UEZATO AU - HIDETOSHI KINJYO AU - YUKASHI YAMASHITA AU - ASANORI KIYUNA AU - KATSUNORI TANAKA AU - SHUNSUKE KONDO AU - HIROYUKI MAEDA AU - MIKIO SUZUKI AU - AKIRA GANAHA Y1 - 2020/06/01 UR - http://ar.iiarjournals.org/content/40/6/3277.abstract N2 - Background/Aim: The aim was to clarify whether DNA repair gene polymorphisms can be used to predict response to cisplatin, 5-fluorouracil, and docetaxel (TPF) as induction chemotherapy (ICT) in Japanese patients with hypopharyngeal cancer (HPC). Materials and Methods: DNA repair gene polymorphisms (rs3212986, rs1799793, rs13181, and rs25487) were analyzed in 117 HPC patients and 125 control subjects by PCR-restriction fragment length polymorphism. Forty-one HPC patients who received TPF-based ICT, followed by surgery or chemoradiotherapy/radiotherapy were analyzed for ICT response, laryngeal preservation, and survival outcome. Results: ICT responders (29 cases) had significantly better overall survival than ICT non-responders (12 cases; 86.0% vs. 37.0%, respectively, p<0.01 by log-rank test) and better laryngeal preservation rates. The DNA repair gene polymorphisms were not related to ICT response. Conclusion: ICT is beneficial for chemoselection of HPC patients, but a role for DNA repair gene polymorphisms in ICT response was not confirmed. ER -