PT  - JOURNAL ARTICLE
AU  - DIRK RADES
AU  - JASPAR WITTELER
AU  - TROELS W. KJAER
AU  - SOEREN TVILSTED
AU  - STEVEN E. SCHILD
TI  - Occurrence of Seizures Prior to Single-fraction Radiosurgery or Multi-fraction Stereotactic Radiotherapy in Patients With Very Few Brain Metastases
AID  - 10.21873/anticanres.14337
DP  - 2020 Jun 01
TA  - Anticancer Research
PG  - 3499--3504
VI  - 40
IP  - 6
4099  - http://ar.iiarjournals.org/content/40/6/3499.short
4100  - http://ar.iiarjournals.org/content/40/6/3499.full
SO  - Anticancer Res2020 Jun 01; 40
AB  - Background/Aim: Seizures represent a major problem for patients with brain metastases. This study evaluated the role of seizures in patients receiving single-fraction radiosurgery (SRS) or multi-fraction stereotactic radiotherapy (FSRT). Patients and Methods: This retrospective study included 195 patients receiving SRS (n=164) or FSRT (n=31) alone for one to three brain metastases. The prevalence of pre-SRS/FSRT seizures and correlations with pre-treatment factors were investigated. These factors plus pre-SRS/FSRT seizures were assessed in regard to survival. Results: Thirty-three patients had pre-SRS/FSRT seizures (prevalence=16.9%). Seizures were significantly correlated with age ≤61 years. Trends were observed for seizures being more frequent in those with NSCLC and those without extra-cranial metastatic spread. On multivariate analysis, significant associations with improved survival were found for Karnofsky performance score ≥80%, breast cancer, and an interval from diagnosis of malignant disease to SRS/FSRT ≥21 months. Conclusion: Younger age, NSCLC and absence of extra-cranial spread appeared to be risk factors for seizures prior to SRS/FSRT. Having seizures prior to SRS/FSRT showed no association with survival.