@article {RADES3499, author = {DIRK RADES and JASPAR WITTELER and TROELS W. KJAER and SOEREN TVILSTED and STEVEN E. SCHILD}, title = {Occurrence of Seizures Prior to Single-fraction Radiosurgery or Multi-fraction Stereotactic Radiotherapy in Patients With Very Few Brain Metastases}, volume = {40}, number = {6}, pages = {3499--3504}, year = {2020}, doi = {10.21873/anticanres.14337}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Seizures represent a major problem for patients with brain metastases. This study evaluated the role of seizures in patients receiving single-fraction radiosurgery (SRS) or multi-fraction stereotactic radiotherapy (FSRT). Patients and Methods: This retrospective study included 195 patients receiving SRS (n=164) or FSRT (n=31) alone for one to three brain metastases. The prevalence of pre-SRS/FSRT seizures and correlations with pre-treatment factors were investigated. These factors plus pre-SRS/FSRT seizures were assessed in regard to survival. Results: Thirty-three patients had pre-SRS/FSRT seizures (prevalence=16.9\%). Seizures were significantly correlated with age <=61 years. Trends were observed for seizures being more frequent in those with NSCLC and those without extra-cranial metastatic spread. On multivariate analysis, significant associations with improved survival were found for Karnofsky performance score >=80\%, breast cancer, and an interval from diagnosis of malignant disease to SRS/FSRT >=21 months. Conclusion: Younger age, NSCLC and absence of extra-cranial spread appeared to be risk factors for seizures prior to SRS/FSRT. Having seizures prior to SRS/FSRT showed no association with survival.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/6/3499}, eprint = {https://ar.iiarjournals.org/content/40/6/3499.full.pdf}, journal = {Anticancer Research} }