TY - JOUR T1 - Second-line Treatment in Advanced Biliary Tract Cancer: Today and Tomorrow JF - Anticancer Research JO - Anticancer Res SP - 3013 LP - 3030 DO - 10.21873/anticanres.14282 VL - 40 IS - 6 AU - ALESSANDRO RIZZO AU - ANGELA DALIA RICCI AU - NASTASSJA TOBER AU - MARIA CONCETTA NIGRO AU - MIRTA MOSCA AU - ANDREA PALLONI AU - FRANCESCA ABBATI AU - GIORGIO FREGA AU - STEFANIA DE LORENZO AU - SIMONA TAVOLARI AU - GIOVANNI BRANDI Y1 - 2020/06/01 UR - http://ar.iiarjournals.org/content/40/6/3013.abstract N2 - Biliary tract cancer (BTC) patients usually have poor prognosis. Whereas combination chemotherapy has been shown to improve survival in the frontline setting, second-line treatment is subject to a lot of debate in the scientific community. Recent data of the ABC-06 trial has provided slight evidence for the use of second-line chemotherapy after progression on cisplatin plus gemcitabine combination. In this study, mFOLFOX plus active symptom control (ASC) improved overall survival (OS) after progression on cisplatin-gemcitabine combination compared with ASC alone, with an increase in 6- and 12-month OS rate. Although genomic studies have paved the way for a new age in cancer management, the “Precision Medicine Era” in BTC is still limited to intrahepatic cholangiocarcinoma and primarily focused on isocitrate dehydrogenase (IDH) and fibroblast growth factor receptor (FGFR) targeted therapies. We herein review recent published data regarding the use of second-line treatment after failure of standard first-line therapies in BTC patients, with a particular focus on ongoing active and recruiting clinical trials. ER -