<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">DENSCHLAG, D.</style></author><author><style face="normal" font="default" size="100%">WATERMANN, D.</style></author><author><style face="normal" font="default" size="100%">HÖRIG, K.</style></author><author><style face="normal" font="default" size="100%">KISSEL, C.</style></author><author><style face="normal" font="default" size="100%">TEMPFER, C.</style></author><author><style face="normal" font="default" size="100%">GITSCH, G.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Topotecan as a Continuous Infusion Over 14 Days in Recurrent Ovarian Cancer Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2004-03-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1267-1270</style></pages><volume><style face="normal" font="default" size="100%">24</style></volume><issue><style face="normal" font="default" size="100%">2C</style></issue><abstract><style  face="normal" font="default" size="100%">Objective: In recurrent ovarian cancer the topoisomerase-1 inhibitor topotecan shows activity after prior treatment with platinum and taxanes. Overall response rates of up to 38% in combination with an acceptable toxicity profile have been reported. We performed a pilot study to evaluate the therapeutic efficacy and toxicity profile of a low-dose continuous infusion protocol of topotecan. Patients and Methods: Twelve patients with recurrent ovarian cancer and a measurable lesion received a continuous infusion of topotecan (0.4mg/m2/d) over 14 days, repeated every 28 days. All patients had at least one prior platinum-containing regimen of chemotherapy (range 1-7). Responses were evaluated by ultrasound, computed tomography (CT) scans and/or magnetic resonance imaging (MRI). Results: A total of 57 (median 5, range 1-12) topotecan treatment cycles were administered. The overall response rate was 2/12 (17%). Four patients had stable disease (33%), among them two patients with platinum-refractory tumors. The median time to progression was 26 (range 20-100) weeks. No grade 3 or 4 hematological toxicities were observed. However, one patient developed a grade 2 allergy leading to discontinuation of topotecan. Conclusion: Treatment of recurrent ovarian cancer with low-dose continuous infusion of topotecan over 14 days demonstrated response rates comparable to other dosing schedules with minimal toxicity in a preliminary series of 12 patients. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>