RT Journal Article
SR Electronic
T1 Prognostic Significance of Soluble Adhesion Molecules in Hodgkin's Disease
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1243
OP 1248
VO 24
IS 2C
A1 K.N. SYRIGOS
A1 E. SALGAMI
A1 A.J. KARAYIANNAKIS
A1 N. KATIRTZOGLOU
A1 E SEKARA
A1 P. ROUSSOU
YR 2004
UL http://ar.iiarjournals.org/content/24/2C/1243.abstract
AB Background: Cell adhesion may play a pivotal role in the development, progression and metastasis of solid malignancies. We evaluated the serum concentration of four adhesion molecules and their prognostic significance in patients with Hodgkin's Disease (HD). Patients and Methods: Serum samples from 20 HD patients were collected at diagnosis, after 3 cycles of chemotherapy and at completion of treatment and compared with a control group of 29 apparently healthy subjects. Soluble forms of E-Selectin (sE-Selectin), ICAM-1 (sICAM-1), VCAM-1 (sVCAM-1) and E-Cadherin (sE-Cad) were measured by standard ELISA assays. Results: Significantly increased serum levels of sICAM-1 and sE-Selectin were determined in HD patients at diagnosis compared to controls (p<0.0001), while sVCAM-1 at diagnosis correlated significantly with both sICAM-1 and sE-Selectin levels (r=0.5, p=0.03). Chemotherapy resulted in a significant decrease of sICAM-1 and sE-Selectin levels (p=0.02 and p=0.002, respectively). Conclusion: Serum levels of ICAM-1 and ESelectin in newly diagnosed HD patients were found significantly increased, suggesting a possible involvement of these two molecules in the pathogenesis of the disease. Their rapid decrease following chemotherapy was found to be an independent predictor of response to treatment. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved