PT  - JOURNAL ARTICLE
AU  - K.N. SYRIGOS
AU  - E. SALGAMI
AU  - A.J. KARAYIANNAKIS
AU  - N. KATIRTZOGLOU
AU  - E SEKARA
AU  - P. ROUSSOU
TI  - Prognostic Significance of Soluble Adhesion Molecules in Hodgkin's Disease
DP  - 2004 Mar 01
TA  - Anticancer Research
PG  - 1243--1248
VI  - 24
IP  - 2C
4099  - http://ar.iiarjournals.org/content/24/2C/1243.short
4100  - http://ar.iiarjournals.org/content/24/2C/1243.full
SO  - Anticancer Res2004 Mar 01; 24
AB  - Background: Cell adhesion may play a pivotal role in the development, progression and metastasis of solid malignancies. We evaluated the serum concentration of four adhesion molecules and their prognostic significance in patients with Hodgkin's Disease (HD). Patients and Methods: Serum samples from 20 HD patients were collected at diagnosis, after 3 cycles of chemotherapy and at completion of treatment and compared with a control group of 29 apparently healthy subjects. Soluble forms of E-Selectin (sE-Selectin), ICAM-1 (sICAM-1), VCAM-1 (sVCAM-1) and E-Cadherin (sE-Cad) were measured by standard ELISA assays. Results: Significantly increased serum levels of sICAM-1 and sE-Selectin were determined in HD patients at diagnosis compared to controls (p<0.0001), while sVCAM-1 at diagnosis correlated significantly with both sICAM-1 and sE-Selectin levels (r=0.5, p=0.03). Chemotherapy resulted in a significant decrease of sICAM-1 and sE-Selectin levels (p=0.02 and p=0.002, respectively). Conclusion: Serum levels of ICAM-1 and ESelectin in newly diagnosed HD patients were found significantly increased, suggesting a possible involvement of these two molecules in the pathogenesis of the disease. Their rapid decrease following chemotherapy was found to be an independent predictor of response to treatment. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved