RT Journal Article
SR Electronic
T1 Nuclear Factor-Î B p65 is a Prognostic Indicator in Gastric Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1071
OP 1076
VO 24
IS 2C
A1 YAMANAKA, NAOKI
A1 SASAKI, NOBUHIKO
A1 TASAKI, AKIRA
A1 NAKASHIMA, HIROSHI
A1 KUBO, MAKOTO
A1 MORISAKI, TAKASHI
A1 NOSHIRO, HIROKAZU
A1 YAO, TAKASHI
A1 TSUNEYOSHI, MASAZUMI
A1 TANAKA, MASAO
A1 KATANO, MITSUO
YR 2004
UL http://ar.iiarjournals.org/content/24/2C/1071.abstract
AB Background: In common with other investigators, we have reported the constitutive activation of transcription factor nuclear factor-Î B (NF-Î B) in a variety of carcinomas, but there is no definite information on its clinical significance. Materials and Methods: NF-Î B p65 activation was determined by immunohistochemical analysis of surgically resected specimens from 63 gastric carcinomas. The 63 patients were divided into a high NF-Î B group (21 patients) and a low NF-Î B group (42 patients). Forty-seven of the 63 patients underwent curative resection. The 47 patients consisted of 13 high NF-Î B patients and 34 low NF-Î B patients. Results: The high NF-Î B group demonstrated a shorter overall survival rate compared with the low NF-Î B group (p=0.015). In the 47 patients who underwent curative resection, the high NF-Î B group also showed a poor survival prognosis (p=0.032). Multivariate analysis indicated that NF-Î B activation is a potential prognostic factor in gastric carcinoma. Conclusion: Constitutive activation of NF-Î B p65 may be a new prognostic parameter in gastric carcinoma. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved