<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">LO MUZIO, L.</style></author><author><style face="normal" font="default" size="100%">LEONARDI, R.</style></author><author><style face="normal" font="default" size="100%">MIGNOGNA, M.D.</style></author><author><style face="normal" font="default" size="100%">PANNONE, G.</style></author><author><style face="normal" font="default" size="100%">RUBINI, C.</style></author><author><style face="normal" font="default" size="100%">PIERAMICI, T.</style></author><author><style face="normal" font="default" size="100%">TREVISIOL, L.</style></author><author><style face="normal" font="default" size="100%">FERRARI, F.</style></author><author><style face="normal" font="default" size="100%">SERPICO, R.</style></author><author><style face="normal" font="default" size="100%">TESTA, N.</style></author><author><style face="normal" font="default" size="100%">DE ROSA, G.</style></author><author><style face="normal" font="default" size="100%">STAIBANO, S.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Scatter Factor Receptor (c-Met) as Possible Prognostic Factor in Patients with Oral Squamous Cell Carcinoma</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2004-03-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1063-1070</style></pages><volume><style face="normal" font="default" size="100%">24</style></volume><issue><style face="normal" font="default" size="100%">2C</style></issue><abstract><style  face="normal" font="default" size="100%">This report was performed to study the biological role of c-Met in oral tumorigenesis by analyzing its expression in relation to clinicopathological features. Seventy-three cases of oral squamous cell carcinoma and 10 of normal mucosa were analysed for c-Met expression by immunohistochemistry. Normal oral squamous epithelium showed absent or low membranous positivity in the intermediate (malpighian - spinous) layer. Fifty-seven cases (78%) of carcinoma showed immunopositivity, with a prevalently membranous positivity and scattered areas also showing a cytoplasmic localization. Sixteen cases of carcinoma (22%) showed no positivity for c-Met. Among positive tumours, well-differentiated areas showed low or absent cytoplasmic positivity, while low-differentiated areas showed both membranous and cytoplasmic positivity. There was no statistically significant correlation between c-Met expression and sex, recurrence, staging or grading. The frequency of lymph node metastases was higher in c-Met-positive tumours (17/57, 29%) than in c-Met-negative ones (4/16, 25%). When analysed for prognostic significance, patients with negative/reduced c-Met expression had better survival rates than patients with high expression. The difference between survival rates was statistically significant (p&lt;0.05). These data suggest that c-Met expression may be useful to identify cases of oral squamous cell carcinoma with a more aggressive and invasive phenotype. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>