RT Journal Article
SR Electronic
T1 Brainstem Glioblastoma Multiforme in a Patient with NF1
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4897
OP 4900
DO 10.21873/anticanres.12804
VO 38
IS 8
A1 JOHN T. FORTUNATO
A1 BRIAN REYS
A1 PAWAN SINGH
A1 EDWARD PAN
YR 2018
UL http://ar.iiarjournals.org/content/38/8/4897.abstract
AB This case report presents the first known case of a brainstem glioblastoma multiforme (GBM) in a patient with neurofibromatosis type 1 (NF1). While research has proposed that larger germ-line mutations in NF1 may be the driving factor that predisposes patients with NF1 to high-grade astrocytomas, this patient had a nonsense mutation in the NF1 gene, suggesting a variant tumorigenesis. Limited data on targeted immunotherapy for NF1 patients with a GBM have been reported and more data are required before targeted therapies could be proven as second-line treatment options.