PT  - JOURNAL ARTICLE
AU  - JOHN T. FORTUNATO
AU  - BRIAN REYS
AU  - PAWAN SINGH
AU  - EDWARD PAN
TI  - Brainstem Glioblastoma Multiforme in a Patient with NF1
AID  - 10.21873/anticanres.12804
DP  - 2018 Aug 01
TA  - Anticancer Research
PG  - 4897--4900
VI  - 38
IP  - 8
4099  - http://ar.iiarjournals.org/content/38/8/4897.short
4100  - http://ar.iiarjournals.org/content/38/8/4897.full
SO  - Anticancer Res2018 Aug 01; 38
AB  - This case report presents the first known case of a brainstem glioblastoma multiforme (GBM) in a patient with neurofibromatosis type 1 (NF1). While research has proposed that larger germ-line mutations in NF1 may be the driving factor that predisposes patients with NF1 to high-grade astrocytomas, this patient had a nonsense mutation in the NF1 gene, suggesting a variant tumorigenesis. Limited data on targeted immunotherapy for NF1 patients with a GBM have been reported and more data are required before targeted therapies could be proven as second-line treatment options.