PT - JOURNAL ARTICLE AU - JOHN T. FORTUNATO AU - BRIAN REYS AU - PAWAN SINGH AU - EDWARD PAN TI - Brainstem Glioblastoma Multiforme in a Patient with NF1 AID - 10.21873/anticanres.12804 DP - 2018 Aug 01 TA - Anticancer Research PG - 4897--4900 VI - 38 IP - 8 4099 - http://ar.iiarjournals.org/content/38/8/4897.short 4100 - http://ar.iiarjournals.org/content/38/8/4897.full SO - Anticancer Res2018 Aug 01; 38 AB - This case report presents the first known case of a brainstem glioblastoma multiforme (GBM) in a patient with neurofibromatosis type 1 (NF1). While research has proposed that larger germ-line mutations in NF1 may be the driving factor that predisposes patients with NF1 to high-grade astrocytomas, this patient had a nonsense mutation in the NF1 gene, suggesting a variant tumorigenesis. Limited data on targeted immunotherapy for NF1 patients with a GBM have been reported and more data are required before targeted therapies could be proven as second-line treatment options.