RT Journal Article
SR Electronic
T1 CD44s Expression is Associated with Improved Survival in Soft Tissue Sarcoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1053
OP 1056
VO 24
IS 2C
A1 MATTHIAS PEIPER
A1 TAKEO SATO
A1 DAVID ZURAKOWSKI
A1 CLAUS EISENBERGER
A1 ANTJE HEINECKE
A1 STEFAN HOSCH
A1 WOLFRAM TRUDO KNOEFEL
YR 2004
UL http://ar.iiarjournals.org/content/24/2C/1053.abstract
AB Expression of CD44 has been identified as a prognostic factor in several malignant diseases. Few studies have correlated CD44 expression in soft tissue sarcoma with subsequent tumor progression or recurrence. We sought to investigate the clinical significance of CD44s (standard) in adult soft tissue sarcoma (STS). Tumor specimens of 62 patients with STS were evaluated by immunohistochemistry for CD44s expression. The primary outcome measures were survival and local recurrence. Of 62 analyzed specimens, 49 tumors were CD44s-positive compared to 13 CD44s-negative tumors. Kaplan-Meier survival analysis indicated significantly better survival among patients whose tumor was CD44s-positive (p=0.015). CD44s expression (hazard ratio, 3.1; 95% confidence interval, 1.5 to 7.0), tumor size (hazard ratio, 11.7; 95% confidence interval, 1.8 to 32.2) and resection quality (R1 vs. R0: hazard ratio, 8.7; 95% confidence interval, 3.1 to 24.5) were independent predictors of survival in multivariate analysis. CD44s expression correlates with prognosis of soft tissue sarcomas and therefore may have a pathogenetic role in tumor progression. Our results suggest that expression of CD44s in primary STS provides value regarding the progression of STS and, therefore, could be useful in selecting patients for adjuvant treatment. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved