RT Journal Article
SR Electronic
T1 Potential Antitumor Agents. 34.(1) Synthesis and Antitumor Activity of Guanylhydrazones from Imidazo[2,1-<em>b</em>]thiazoles and from Diimidazo[1,2-<em>a</em>:1,2-<em>c</em>]pyrimidine
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 203
OP 212
VO 24
IS 1
A1 ANDREANI, ALDO
A1 GRANAIOLA, MASSIMILIANO
A1 LEONI, ALBERTO
A1 LOCATELLI, ALESSANDRA
A1 MORIGI, RITA
A1 RAMBALDI, MIRELLA
A1 GIORGI, GIANLUCA
A1 GARALIENE, VIDA
YR 2004
UL http://ar.iiarjournals.org/content/24/1/203.abstract
AB We report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described.