RT Journal Article SR Electronic T1 Potential Antitumor Agents. 34.(1) Synthesis and Antitumor Activity of Guanylhydrazones from Imidazo[2,1-b]thiazoles and from Diimidazo[1,2-a:1,2-c]pyrimidine JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 203 OP 212 VO 24 IS 1 A1 ANDREANI, ALDO A1 GRANAIOLA, MASSIMILIANO A1 LEONI, ALBERTO A1 LOCATELLI, ALESSANDRA A1 MORIGI, RITA A1 RAMBALDI, MIRELLA A1 GIORGI, GIANLUCA A1 GARALIENE, VIDA YR 2004 UL http://ar.iiarjournals.org/content/24/1/203.abstract AB We report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described.