PT  - JOURNAL ARTICLE
AU  - ANDREANI, ALDO
AU  - GRANAIOLA, MASSIMILIANO
AU  - LEONI, ALBERTO
AU  - LOCATELLI, ALESSANDRA
AU  - MORIGI, RITA
AU  - RAMBALDI, MIRELLA
AU  - GIORGI, GIANLUCA
AU  - GARALIENE, VIDA
TI  - Potential Antitumor Agents. 34.(1) Synthesis and Antitumor Activity of Guanylhydrazones from Imidazo[2,1-<em>b</em>]thiazoles and from Diimidazo[1,2-<em>a</em>:1,2-<em>c</em>]pyrimidine
DP  - 2004 Jan 01
TA  - Anticancer Research
PG  - 203--212
VI  - 24
IP  - 1
4099  - http://ar.iiarjournals.org/content/24/1/203.short
4100  - http://ar.iiarjournals.org/content/24/1/203.full
SO  - Anticancer Res2004 Jan 01; 24
AB  - We report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described.