PT - JOURNAL ARTICLE AU - ANDREANI, ALDO AU - GRANAIOLA, MASSIMILIANO AU - LEONI, ALBERTO AU - LOCATELLI, ALESSANDRA AU - MORIGI, RITA AU - RAMBALDI, MIRELLA AU - GIORGI, GIANLUCA AU - GARALIENE, VIDA TI - Potential Antitumor Agents. 34.(1) Synthesis and Antitumor Activity of Guanylhydrazones from Imidazo[2,1-<em>b</em>]thiazoles and from Diimidazo[1,2-<em>a</em>:1,2-<em>c</em>]pyrimidine DP - 2004 Jan 01 TA - Anticancer Research PG - 203--212 VI - 24 IP - 1 4099 - http://ar.iiarjournals.org/content/24/1/203.short 4100 - http://ar.iiarjournals.org/content/24/1/203.full SO - Anticancer Res2004 Jan 01; 24 AB - We report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described.