RT Journal Article
SR Electronic
T1 Computational Simulation of Chronic Persistent Virus Infection: Factors Determining Differences in Clinical Outcome of HHV-6, HIV-1 and HTLV-1 Infections Including Aplastic, Hyperplastic and Neoplastic Responses
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 187
OP 198
VO 24
IS 1
A1 G.R.F. KRUEGER
A1 M.E. BRANDT
A1 G. WANG
A1 L.M. BUJA
YR 2004
UL http://ar.iiarjournals.org/content/24/1/187.abstract
AB A computational model was recently designed to simulate cellular changes in the T cell immune system. The model was validated by simulating cell changes in viral infections which target the same CD4+ T cell, yet cause either hyperplastic, aplastic or neoplastic responses. Respective case material for comparison was available from human infections with human herpesvirus-6 (HHV-6), human immunodeficiency virus (HIV-1) or human T cell leukemia virus (HTLV-1). Starting with cell values for a healthy human individual, factorial changes that influence the individual course of the various infections were determined by an algorithm search procedure. Such factorial differences determining a clinical course with aplasia, hyperplasia or neoplasia are outlined and further discussed in this paper.