TY - JOUR T1 - Computational Simulation of Chronic Persistent Virus Infection: Factors Determining Differences in Clinical Outcome of HHV-6, HIV-1 and HTLV-1 Infections Including Aplastic, Hyperplastic and Neoplastic Responses JF - Anticancer Research JO - Anticancer Res SP - 187 LP - 198 VL - 24 IS - 1 AU - G.R.F. KRUEGER AU - M.E. BRANDT AU - G. WANG AU - L.M. BUJA Y1 - 2004/01/01 UR - http://ar.iiarjournals.org/content/24/1/187.abstract N2 - A computational model was recently designed to simulate cellular changes in the T cell immune system. The model was validated by simulating cell changes in viral infections which target the same CD4+ T cell, yet cause either hyperplastic, aplastic or neoplastic responses. Respective case material for comparison was available from human infections with human herpesvirus-6 (HHV-6), human immunodeficiency virus (HIV-1) or human T cell leukemia virus (HTLV-1). Starting with cell values for a healthy human individual, factorial changes that influence the individual course of the various infections were determined by an algorithm search procedure. Such factorial differences determining a clinical course with aplasia, hyperplasia or neoplasia are outlined and further discussed in this paper. ER -