RT Journal Article SR Electronic T1 HIF Transcription Factor Expression and Induction of Hypoxic Response Genes in a Retroperitoneal Angiosarcoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 167 OP 170 VO 24 IS 1 A1 W. KIMRYN RATHMELL A1 GEZA ACS A1 M. CELESTE SIMON A1 DAVID J. VAUGHN YR 2004 UL http://ar.iiarjournals.org/content/24/1/167.abstract AB Angiosarcoma is a rare and highly aggressive tumor of endothelial origin. The molecular mechanisms driving angiosarcoma growth have not been fully elucidated, although autocrine stimulation by vascular endothelial growth factor (VEGF) secretion may play a role in the pathogenesis of this tumor. We identified a patient with a very rare form of angiosarcoma arising from the retroperitoneum. Immunohistochemical analysis demonstrated widespread upregulation of the hypoxic response pathway as a mechanism of enhanced VEGF expression. Disordered regulation of the hypoxic response pathway can result in the expression of factors such as VEGF and erythropoietin, which may promote autocrine tumor growth in angiosarcoma.