PT  - JOURNAL ARTICLE
AU  - W. KIMRYN RATHMELL
AU  - GEZA ACS
AU  - M. CELESTE SIMON
AU  - DAVID J. VAUGHN
TI  - HIF Transcription Factor Expression and Induction of Hypoxic Response Genes in a Retroperitoneal Angiosarcoma
DP  - 2004 Jan 01
TA  - Anticancer Research
PG  - 167--170
VI  - 24
IP  - 1
4099  - http://ar.iiarjournals.org/content/24/1/167.short
4100  - http://ar.iiarjournals.org/content/24/1/167.full
SO  - Anticancer Res2004 Jan 01; 24
AB  - Angiosarcoma is a rare and highly aggressive tumor of endothelial origin. The molecular mechanisms driving angiosarcoma growth have not been fully elucidated, although autocrine stimulation by vascular endothelial growth factor (VEGF) secretion may play a role in the pathogenesis of this tumor. We identified a patient with a very rare form of angiosarcoma arising from the retroperitoneum. Immunohistochemical analysis demonstrated widespread upregulation of the hypoxic response pathway as a mechanism of enhanced VEGF expression. Disordered regulation of the hypoxic response pathway can result in the expression of factors such as VEGF and erythropoietin, which may promote autocrine tumor growth in angiosarcoma.