TY - JOUR T1 - Methylenetetrahydrofolate Reductase (<em>MTHFR</em>) Genotype, Smoking Habit, Metastasis and Oral Cancer in Taiwan JF - Anticancer Research JO - Anticancer Res SP - 2395 LP - 2399 VL - 31 IS - 6 AU - CHIA-WEN TSAI AU - CHIA-FANG HSU AU - MING-HSUI TSAI AU - YUNG-AN TSOU AU - CHUN-HUNG HUA AU - WEN-SHIN CHANG AU - CHENG-CHIEH LIN AU - DA-TIAN BAU Y1 - 2011/06/01 UR - http://ar.iiarjournals.org/content/31/6/2395.abstract N2 - The aim of this study was to evaluate the association and interaction of genotypic polymorphism in methylenetetrahydrofolate reductase (MTHFR) with smoking habits and oral cancer in Taiwan. Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed in association with oral cancer risk, and their joint effects with individual smoking habits on oral cancer risk are discussed. In total, 620 oral cancer patients and 620 non-cancer controls in central Taiwan were recruited and genotyped. The MTHFR C677T genotype, but not the A1298C, was differently distributed between the oral cancer and control groups. The T allele of MTHFR C677T was significantly more frequently found in controls than in oral cancer patients. Joint effects of smoking and MTHFR C677T genotype significantly affected oral cancer susceptibility. The MTHFR C677T CT and TT genotypes in association with smoking conferred lower odds ratios of 0.66 and 0.54 (95% confidence interval=0.49-0.82 and 0.39-0.86), respectively. Those patients with MTHFR C677T CT and TT genotypes also had a lower risk of oral cancer metastasis. MTHFR C677T genotype may have joint effects with smoking on oral carcinogenesis, and may be a useful biomarker for prediction and prognosis of oral cancer. ER -