TY - JOUR T1 - Chemical Composition and Antiproliferative Activity of Essential Oil from the Leaves of a Medicinal Herb, <em>Levisticum officinale,</em> against UMSCC1 Head and Neck Squamous Carcinoma Cells JF - Anticancer Research JO - Anticancer Res SP - 185 LP - 191 VL - 31 IS - 1 AU - SERKAN SERTEL AU - TOLGA EICHHORN AU - PETER K. PLINKERT AU - THOMAS EFFERTH Y1 - 2011/01/01 UR - http://ar.iiarjournals.org/content/31/1/185.abstract N2 - Background: Oral squamous cell carcinoma (OSCC) is a challenging disease with a high mortality rate. Natural products represent a valuable source for the development of novel anticancer drugs. We investigated the cytotoxic potential of essential oil from the leaves of a medicinal plant, Levisticum officinale (lovage) on head and neck squamous carcinoma cells (HNSCC). Materials and Methods: Cytotoxicity of lovage essential oil was investigated on the HNSCC cell line, UMSCC1. Additionally, we performed pharmacogenomics analyses. Results: Lovage essential oil extract had an IC50 value of 292.6 μg/ml. Genes involved in apoptosis, cancer, cellular growth and cell cycle regulation were the most prominently affected in microarray analyses. The three pathways to be most significantly regulated were extracellular signal-regulated kinase 5 (ERK5) signaling, integrin-linked kinase (ILK) signaling, virus entry via endocytic pathways and p53 signaling. Conclusion: Levisticum officinale essential oil inhibits human HNSCC cell growth. ER -