TY - JOUR T1 - Seizures and Tumor Progression in Glioma Patients with Uncontrollable Epilepsy Treated with Perampanel JF - Anticancer Research JO - Anticancer Res SP - 4361 LP - 4366 DO - 10.21873/anticanres.12737 VL - 38 IS - 7 AU - SHUICHI IZUMOTO AU - MASAHARU MIYAUCHI AU - TAKAYUKI TASAKI AU - TAKESHI OKUDA AU - NOBUHIRO NAKAGAWA AU - NAOKI NAKANO AU - AMAMI KATO AU - MITSUGU FUJITA Y1 - 2018/07/01 UR - http://ar.iiarjournals.org/content/38/7/4361.abstract N2 - Background/Aim: Excessive extracellular glutamate activates AMPA-type glutamate receptors (AMPA receptors) and induces seizures. Antagonistic activation of AMPA receptors inhibits epilepsy and glioma growth in in vitro and in vivo studies. This study was conducted to evaluate the clinical impacts of perampanel (PER), a novel AMPA receptor antagonist, on seizures and tumor progression in glioma patients with uncontrollable epilepsy. Patients and Methods: Twelve glioma patients with uncontrollable epilepsy were treated with PER. Seizure response, PER concentration, and tumor volume were assessed. Results: Obvious seizure control was observed in 10 analyzed patients (100%) and 6 patients (60%) became seizure-free. Median plasma concentrations of PER were 296 ng/ml in those with 4 mg/day PER treatment and 518 ng/ml in those with 8 mg/day PER treatment. High-intensity lesions in fluid-attenuated inversion recovery of magnetic resonance imaging (MRI) were volumetrically assessed to analyze tumor size. Volume reduction was detected within 6 months in correlation with increased plasma levels of PER. Conclusion: PER treatment was effective in uncontrollable epilepsy with gliomas. MRI images showed the inhibition of tumor growth. ER -