PT  - JOURNAL ARTICLE
AU  - SHUICHI IZUMOTO
AU  - MASAHARU MIYAUCHI
AU  - TAKAYUKI TASAKI
AU  - TAKESHI OKUDA
AU  - NOBUHIRO NAKAGAWA
AU  - NAOKI NAKANO
AU  - AMAMI KATO
AU  - MITSUGU FUJITA
TI  - Seizures and Tumor Progression in Glioma Patients with Uncontrollable Epilepsy Treated with Perampanel
AID  - 10.21873/anticanres.12737
DP  - 2018 Jul 01
TA  - Anticancer Research
PG  - 4361--4366
VI  - 38
IP  - 7
4099  - http://ar.iiarjournals.org/content/38/7/4361.short
4100  - http://ar.iiarjournals.org/content/38/7/4361.full
SO  - Anticancer Res2018 Jul 01; 38
AB  - Background/Aim: Excessive extracellular glutamate activates AMPA-type glutamate receptors (AMPA receptors) and induces seizures. Antagonistic activation of AMPA receptors inhibits epilepsy and glioma growth in in vitro and in vivo studies. This study was conducted to evaluate the clinical impacts of perampanel (PER), a novel AMPA receptor antagonist, on seizures and tumor progression in glioma patients with uncontrollable epilepsy. Patients and Methods: Twelve glioma patients with uncontrollable epilepsy were treated with PER. Seizure response, PER concentration, and tumor volume were assessed. Results: Obvious seizure control was observed in 10 analyzed patients (100%) and 6 patients (60%) became seizure-free. Median plasma concentrations of PER were 296 ng/ml in those with 4 mg/day PER treatment and 518 ng/ml in those with 8 mg/day PER treatment. High-intensity lesions in fluid-attenuated inversion recovery of magnetic resonance imaging (MRI) were volumetrically assessed to analyze tumor size. Volume reduction was detected within 6 months in correlation with increased plasma levels of PER. Conclusion: PER treatment was effective in uncontrollable epilepsy with gliomas. MRI images showed the inhibition of tumor growth.