RT Journal Article
SR Electronic
T1 Impact of the Lysine-urethane Adhesive TissuGlu® on Postoperative Complications and Interventions After Drain-free Mastectomy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2801
OP 2812
DO 10.21873/anticanres.14253
VO 40
IS 5
A1 RALF OHLINGER
A1 RICO RUTKOWSKI
A1 THOMAS KOHLMANN
A1 STEFAN PAEPKE
A1 ZAHER ALWAFAI
A1 CAROLIN FLIEGER
A1 SYLKE MÖLLER
A1 FRANZISKA LENZ
A1 MAREK ZYGMUNT
A1 JULIA UNGER
YR 2020
UL http://ar.iiarjournals.org/content/40/5/2801.abstract
AB Background/Aim: The influence of a polyurethane-based tissue adhesive (TissuGlu®) on common complications following breast surgery was investigated. Patients and Methods: Within a Randomized-Controlled-Trial 70 women (n=35 TissuGlu®, n=35 drain) underwent a mastectomy with or without sentinel lymph node excision (SLNE), followed by a 90-day postoperative follow-up. Results: Postoperative interventions: Non-inferiority of the application of TissuGlu® was seen. Pain-Level/ Hospitalization: A statistically significant pain reduction from day four onwards (p<0.001) and a shorter hospitalization period (p<0.001) was observed. In contrast, the TissuGlu® group showed increased mean puncture incidence (p=0.013), and increased puncture volume (p=0.021). Conclusion: Application of the polyurethane-based tissue adhesive TissuGlu® after mastectomy, with or without SLNE, showed potential for improvement of the clinical outcome. In contrast, high intervention rates and increased puncture volume, caused by recurring seromas following application of the surgical adhesive TissuGlu®, have a negative impact on the patient-specific convalescence.