RT Journal Article SR Electronic T1 Whole-bladder Radiation Therapy for Lymph Node-negative Bladder Cancer With Muscle Invasion in Elderly Patients JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2905 OP 2909 DO 10.21873/anticanres.14267 VO 40 IS 5 A1 AKIKO ADACHI A1 HIDEMASA KAWAMURA A1 DAISAKU YOSHIDA A1 MASAHIRO KAWAHARA A1 SHIGEHIRO KUDO A1 TAKASHI EBARA A1 TAKASHI NAKANO YR 2020 UL http://ar.iiarjournals.org/content/40/5/2905.abstract AB Background: The Japanese bladder cancer treatment guidelines recommend concurrent chemoradiotherapy, including wide pelvic irradiation. Many elderly patients, however, cannot tolerate standard treatment because of low performance status. Therefore, to reduce complications, elderly patients sometimes receive radiation therapy without elective nodal irradiation or chemotherapy. Patients and Methods: Outcomes were retrospectively analyzed in 19 elderly patients with N0 muscle-invasive bladder cancer treated with whole-bladder irradiation without chemotherapy. Results: The 3- and 5-year overall survival rates were 30.7% and 12.2%, respectively. No patient experienced severe late complications (grade 3 or higher). Recurrence was observed in 11 patients (57.9%). The initial location of recurrence was within the bladder. Conclusion: Whole-bladder irradiation alone did not increase lymph node metastases or severe complications in elderly patients. Whole-bladder radiation therapy without chemotherapy or wide pelvic irradiation may be a promising treatment method for patients who are not candidates for standardized treatment.