TY - JOUR T1 - Impact of Cytoreductive Surgery and HIPEC on Intraoperative Gastrointestinal Wall Thickness and Patient Outcomes JF - Anticancer Research JO - Anticancer Res SP - 2865 LP - 2869 DO - 10.21873/anticanres.14262 VL - 40 IS - 5 AU - MICHELLE ZHIYUN CHEN AU - DANIEL L. CHAN AU - MOHAMMAD S. ALSHAHRANI AU - KHALED ALTOUKHI AU - NAYEF ALZAHRANI AU - DAVID L. MORRIS Y1 - 2020/05/01 UR - http://ar.iiarjournals.org/content/40/5/2865.abstract N2 - Background: Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is associated with significant postoperative ileus (POI). This study examined intraoperative gastrointestinal wall thickness (GWT) and its association with patient outcomes. Patients and Methods: A prospective study of patients undergoing CRS and HIPEC. Proximal and distal small intestine GWT, before and after HIPEC were recorded. Results: Thirty-four patients (mean age=56.1 years, 61.8% female) were recruited. After HIPEC, the mean proximal (4.5 vs. 3.0 mm, p=0.03) and distal (4.3 vs. 3.4 mm, p<0.01) GWT were increased. Increased GWT was associated with prolonged operative time (10 vs. 8.5 h, p=0.03) and total length of stay (35.71 vs. 21.25 days, p=0.02). Postoperative ileus occurred in 23.5% of patients but differences between GWT groups did not reach significance (28.6% vs. 20%, p=0.56). Conclusion: GWT increased significantly during CRS and HIPEC and is reflective of tissue trauma and oedema. This was associated with prolonged operative time, total length of stay and post-operative ileus. ER -