TY - JOUR T1 - Preoperative Neutrophil-to-lymphocyte Ratio Predicts Tumor-infiltrating CD8<sup>+</sup> T Cells in Biliary Tract Cancer JF - Anticancer Research JO - Anticancer Res SP - 2881 LP - 2887 DO - 10.21873/anticanres.14264 VL - 40 IS - 5 AU - RYOTA TANAKA AU - KENJIRO KIMURA AU - SHINPEI EGUCHI AU - JUN TAUCHI AU - MASATUNE SHIBUTANI AU - HIROJI SHINKAWA AU - GO OHIRA AU - SADAAKI YAMAZOE AU - SHOGO TANAKA AU - RYOSUKE AMANO AU - HIROAKI TANAKA AU - MASAKAZU YASHIRO AU - SHOJI KUBO AU - MASAICHI OHIRA Y1 - 2020/05/01 UR - http://ar.iiarjournals.org/content/40/5/2881.abstract N2 - Background/Aim: This study evaluated the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR) and CD8+ tumor-infiltrating lymphocytes (TILs), and whether preoperative NLR was associated with CD8+ TILs in biliary tract cancers (BTCs). Patients and Methods: A total of 154 patients with BTCs who underwent surgery were enrolled in this study. We obtained neutrophil and lymphocyte counts, and calculated NLR from preoperative peripheral blood samples. CD8+ TILs were identified by immunohistochemical staining. Results: The overall survival (OS) and recurrence-free survival (RFS) of patients with high NLR were shorter than those with low NLR. The OS and RFS of patients with high CD8+ TILs were longer than those with low CD8+ TILs. Preoperative NLR and CD8+ TILs were negatively correlated. Conclusion: NLR and CD8+ TILs were associated with OS and RFS in BTCs. NLR can predict CD8+ TILs infiltrating the cancer microenvironment. ER -