PT  - JOURNAL ARTICLE
AU  - TANAKA, RYOTA
AU  - KIMURA, KENJIRO
AU  - EGUCHI, SHINPEI
AU  - TAUCHI, JUN
AU  - SHIBUTANI, MASATUNE
AU  - SHINKAWA, HIROJI
AU  - OHIRA, GO
AU  - YAMAZOE, SADAAKI
AU  - TANAKA, SHOGO
AU  - AMANO, RYOSUKE
AU  - TANAKA, HIROAKI
AU  - YASHIRO, MASAKAZU
AU  - KUBO, SHOJI
AU  - OHIRA, MASAICHI
TI  - Preoperative Neutrophil-to-lymphocyte Ratio Predicts Tumor-infiltrating CD8<sup>+</sup> T Cells in Biliary Tract Cancer
AID  - 10.21873/anticanres.14264
DP  - 2020 May 01
TA  - Anticancer Research
PG  - 2881--2887
VI  - 40
IP  - 5
4099  - http://ar.iiarjournals.org/content/40/5/2881.short
4100  - http://ar.iiarjournals.org/content/40/5/2881.full
SO  - Anticancer Res2020 May 01; 40
AB  - Background/Aim: This study evaluated the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR) and CD8+ tumor-infiltrating lymphocytes (TILs), and whether preoperative NLR was associated with CD8+ TILs in biliary tract cancers (BTCs). Patients and Methods: A total of 154 patients with BTCs who underwent surgery were enrolled in this study. We obtained neutrophil and lymphocyte counts, and calculated NLR from preoperative peripheral blood samples. CD8+ TILs were identified by immunohistochemical staining. Results: The overall survival (OS) and recurrence-free survival (RFS) of patients with high NLR were shorter than those with low NLR. The OS and RFS of patients with high CD8+ TILs were longer than those with low CD8+ TILs. Preoperative NLR and CD8+ TILs were negatively correlated. Conclusion: NLR and CD8+ TILs were associated with OS and RFS in BTCs. NLR can predict CD8+ TILs infiltrating the cancer microenvironment.