%0 Journal Article %A RYOTA TANAKA %A KENJIRO KIMURA %A SHINPEI EGUCHI %A JUN TAUCHI %A MASATUNE SHIBUTANI %A HIROJI SHINKAWA %A GO OHIRA %A SADAAKI YAMAZOE %A SHOGO TANAKA %A RYOSUKE AMANO %A HIROAKI TANAKA %A MASAKAZU YASHIRO %A SHOJI KUBO %A MASAICHI OHIRA %T Preoperative Neutrophil-to-lymphocyte Ratio Predicts Tumor-infiltrating CD8+ T Cells in Biliary Tract Cancer %D 2020 %R 10.21873/anticanres.14264 %J Anticancer Research %P 2881-2887 %V 40 %N 5 %X Background/Aim: This study evaluated the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR) and CD8+ tumor-infiltrating lymphocytes (TILs), and whether preoperative NLR was associated with CD8+ TILs in biliary tract cancers (BTCs). Patients and Methods: A total of 154 patients with BTCs who underwent surgery were enrolled in this study. We obtained neutrophil and lymphocyte counts, and calculated NLR from preoperative peripheral blood samples. CD8+ TILs were identified by immunohistochemical staining. Results: The overall survival (OS) and recurrence-free survival (RFS) of patients with high NLR were shorter than those with low NLR. The OS and RFS of patients with high CD8+ TILs were longer than those with low CD8+ TILs. Preoperative NLR and CD8+ TILs were negatively correlated. Conclusion: NLR and CD8+ TILs were associated with OS and RFS in BTCs. NLR can predict CD8+ TILs infiltrating the cancer microenvironment. %U https://ar.iiarjournals.org/content/anticanres/40/5/2881.full.pdf