TY - JOUR T1 - Association of Nijmegen Breakage Syndrome 1 Genotypes With Bladder Cancer Risk JF - Anticancer Research JO - Anticancer Res SP - 2011 LP - 2017 DO - 10.21873/anticanres.14157 VL - 40 IS - 4 AU - MENG CHEN AU - WEN-SHIN CHANG AU - TE-CHUN SHEN AU - CHI-LI GONG AU - MENG-LIANG LIN AU - ZHI-HONG WANG AU - YUN-CHI WANG AU - CHAO-HSUAN CHEN AU - HSI-CHIN WU AU - DA-TIAN BAU AU - CHIA-WEN TSAI Y1 - 2020/04/01 UR - http://ar.iiarjournals.org/content/40/4/2011.abstract N2 - Background/Aim: We aimed to examine the association of the genotypes of Nijmegen breakage syndrome 1 (NBS1), a critical gene in DNA double strand break repair machinery, with bladder cancer risk in Taiwan. Materials and Methods: NBS1 rs1805794 genotypes among 375 bladder cancer patients and 375 non-cancer healthy controls were determined via the polymerase chain reaction-restriction fragment length polymorphism methodology and their association with bladder cancer risk were evaluated. Results: The results showed that the percentages of GG, CG and CC of NBS1 rs1805794 genotypes were 45.4%, 43.7% and 10.9% in the bladder cancer patient group and 47.2%, 43.2% and 9.6% in the non-cancer control group, respectively (p for trend=0.7873). The analysis of allelic frequency distributions showed that the variant C allele of NBS1 rs1805794 does not contribute to an increased bladder cancer susceptibility (p=0.5066). Conclusion: The genotypes of NBS1 rs1805794 are not closely associated with personal susceptibility to bladder cancer. ER -