PT  - JOURNAL ARTICLE
AU  - YOTA SHIMODA
AU  - TAKANOBU YAMADA
AU  - KEISUKE KOMORI
AU  - HAYATO WATANABE
AU  - HIROAKI OSAKABE
AU  - KAZUKI KANO
AU  - HIROHITO FUJIKAWA
AU  - TSUTOMU HAYASHI
AU  - HARUHIKO CHO
AU  - MANABU SHIOZAWA
AU  - TAKAKI YOSHIKAWA
AU  - SOICHIRO MORINAGA
AU  - YOSHIHIRO OTA
AU  - KENJI KATSUMATA
AU  - AKIHIKO TSUCHIDA
AU  - TAKASHI OGATA
AU  - TAKASHI OSHIMA
TI  - Effect of Muscle Mass Loss After Esophagectomy on Prognosis of Oesophageal Cancer
AID  - 10.21873/anticanres.14192
DP  - 2020 Apr 01
TA  - Anticancer Research
PG  - 2275--2281
VI  - 40
IP  - 4
4099  - http://ar.iiarjournals.org/content/40/4/2275.short
4100  - http://ar.iiarjournals.org/content/40/4/2275.full
SO  - Anticancer Res2020 Apr 01; 40
AB  - Background/Aim: To assess the prognostic effect of muscle loss after esophagectomy and before discharge. Patients and Methods: This study retrospectively analysed 159 consecutive patients with oesophageal and gastroesophageal junction cancer who underwent esophagectomy between August 2011 and October 2015. Body composition was evaluated one week before surgery and at discharge using a bioelectrical impedance analyser. Results: The median rate of muscle mass loss (RMML) was 4.38% (range=−3.3 to +18.8). Patients with increased RMML had significantly poorer outcomes of overall survival than those with decreased RMML (p=0.015). On multivariate analysis, RMML [≥4.38, hazard ratio (HR)=2.033, 95% confidence interval (CI)=1.018-5.924, p=0.044) and pathological tumour depth (≥2, HR=3.099, 95%CI=1.339-7.172, p=0.008) were selected as independent prognostic factors. Conclusion: RMML after esophagectomy is indicative of poor prognosis in patients with esophageal cancer.