RT Journal Article
SR Electronic
T1 Experimental Animal Model of Re-irradiation to Evaluate Radiation-induced Damage in the Normal Intestine
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1981
OP 1988
DO 10.21873/anticanres.14153
VO 40
IS 4
A1 HIROSHI DOI
A1 MIKOTO TAMURA
A1 KIYOSHI NAKAMATSU
A1 HAJIME MONZEN
A1 YASUMASA NISHIMURA
YR 2020
UL http://ar.iiarjournals.org/content/40/4/1981.abstract
AB Background/Aim: We aimed to elucidate the pathological findings following acute and late re-irradiation in a preclinical model. Materials and Methods: Mice were divided into five treatment groups: sham-irradiation (Sham-IR), 10-12 Gy (Single IR Acute), 15 Gy (Single IR Late), 15 Gy followed by 10-12 Gy re-irradiation 7 days later (Re-IR Acute), or 15 Gy followed by 10-12 Gy re-irradiation 12 weeks later (Re-IR Late). Mice were sacrificed after either single irradiation or re-irradiation for pathological assessment. Results: The Re-IR Late group had significantly lower numbers of crypts with apoptotic cells than those observed in mice in the Single IR Acute group. There were no significant differences between the Single IR Acute and re-IR Acute groups in cell proliferation or in a crypt survival assay. Conclusion: Re-irradiation with a long interval after the first irradiation may cause similar acute biological effects in normal intestine as observed following irradiation without re-irradiation.