PT  - JOURNAL ARTICLE
AU  - HIROSHI DOI
AU  - MIKOTO TAMURA
AU  - KIYOSHI NAKAMATSU
AU  - HAJIME MONZEN
AU  - YASUMASA NISHIMURA
TI  - Experimental Animal Model of Re-irradiation to Evaluate Radiation-induced Damage in the Normal Intestine
AID  - 10.21873/anticanres.14153
DP  - 2020 Apr 01
TA  - Anticancer Research
PG  - 1981--1988
VI  - 40
IP  - 4
4099  - http://ar.iiarjournals.org/content/40/4/1981.short
4100  - http://ar.iiarjournals.org/content/40/4/1981.full
SO  - Anticancer Res2020 Apr 01; 40
AB  - Background/Aim: We aimed to elucidate the pathological findings following acute and late re-irradiation in a preclinical model. Materials and Methods: Mice were divided into five treatment groups: sham-irradiation (Sham-IR), 10-12 Gy (Single IR Acute), 15 Gy (Single IR Late), 15 Gy followed by 10-12 Gy re-irradiation 7 days later (Re-IR Acute), or 15 Gy followed by 10-12 Gy re-irradiation 12 weeks later (Re-IR Late). Mice were sacrificed after either single irradiation or re-irradiation for pathological assessment. Results: The Re-IR Late group had significantly lower numbers of crypts with apoptotic cells than those observed in mice in the Single IR Acute group. There were no significant differences between the Single IR Acute and re-IR Acute groups in cell proliferation or in a crypt survival assay. Conclusion: Re-irradiation with a long interval after the first irradiation may cause similar acute biological effects in normal intestine as observed following irradiation without re-irradiation.