PT  - JOURNAL ARTICLE
AU  - RADES, DIRK
AU  - NGUYEN, TRANG
AU  - KHOA, MAI TRONG
AU  - JANSSEN, STEFAN
AU  - SCHILD, STEVEN E.
TI  - Remaining Lifespan of Patients Aged ≥65 Years Receiving Whole-brain Irradiation for Metastases from Cancer of Unknown Primary
AID  - 10.21873/anticanres.14189
DP  - 2020 Apr 01
TA  - Anticancer Research
PG  - 2261--2264
VI  - 40
IP  - 4
4099  - http://ar.iiarjournals.org/content/40/4/2261.short
4100  - http://ar.iiarjournals.org/content/40/4/2261.full
SO  - Anticancer Res2020 Apr 01; 40
AB  - Background/Aim: Personalized therapies may improve outcomes in elderly patients with brain metastases from cancer of unknown primary (CUP). To contribute to this strategy, an instrument for judging their survival time was designed. Patients and Methods: This retrospective study included 53 patients, aged ≥65 years and treated with whole-brain irradiation (WBI) for brain metastases from CUP. The WBI-program, age, gender, Karnofsky performance score (KPS), number of brain metastases and non-cerebral metastases were analyzed. Results: KPS≤60 (p<0.001) and presence of non-cerebral metastases (p=0.003) were significantly associated with unfavorable survival. These factors formed the basis for the prognostic implement; patient-scores of zero (n=23), one (n=21) or two points (n=9) were obtained. Corresponding survival rates at 6-months were 0%, 19% and 56% (p<0.001). Conclusion: With this instrument, it is easier to judge the remaining survival time of elderly patients with brain metastases from CUP. This information should be used when selecting individual treatment- and WBI-programs.