RT Journal Article
SR Electronic
T1 Diagnostic Value of FDG-PET/CT for the Identification of Extranodal Extension in Patients With Head and Neck Squamous Cell Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2073
OP 2077
DO 10.21873/anticanres.14165
VO 40
IS 4
A1 TOYA, RYO
A1 SAITO, TETSUO
A1 MATSUYAMA, TOMOHIKO
A1 KAI, YUDAI
A1 SHIRAISHI, SHINYA
A1 MURAKAMI, DAIZO
A1 YOSHIDA, RYOJI
A1 WATAKABE, TAKAHIRO
A1 SAKAMOTO, FUMI
A1 TSUDA, NORIKO
A1 ARIMURA, HIDETAKA
A1 ORITA, YORIHISA
A1 NAKAYAMA, HIDEKI
A1 OYA, NATSUO
YR 2020
UL http://ar.iiarjournals.org/content/40/4/2073.abstract
AB Background/Aim: We evaluated the diagnostic value of functional imaging with [18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) for the identification of extranodal extension (ENE) in patients with head and neck squamous cell carcinoma (HNSCC). Patients and Methods: In this study, 94 patients with HNSCC who underwent FDG-PET/CT were enrolled. We recorded the maximum standardized uptake value (SUVmax), compared the results with pathologic findings, and evaluated the diagnostic performance of using a SUVmax cut-off value for ENE. Results: Of the 566 dissected levels examined, 53 (9.4%) exhibited ENE. The mean SUVmax of LN with and without ENE were 6.67 and 1.64, respectively (p<0.001). A receiver operating characteristics (ROC) curve analysis for SUVmax showed an area under the ROC curve of 0.913. A SUVmax cut-off of 3.0 achieved diagnostic performance for identifying ENE with sensitivity, specificity, and accuracy of 81.1%, 94.3% and 93.1%, respectively. Conclusion: FDG-PET/CT findings using a SUVmax cut-off of 3.0 provides appropriate diagnostic value in identifying ENE.