PT  - JOURNAL ARTICLE
AU  - RYO TOYA
AU  - TETSUO SAITO
AU  - TOMOHIKO MATSUYAMA
AU  - YUDAI KAI
AU  - SHINYA SHIRAISHI
AU  - DAIZO MURAKAMI
AU  - RYOJI YOSHIDA
AU  - TAKAHIRO WATAKABE
AU  - FUMI SAKAMOTO
AU  - NORIKO TSUDA
AU  - HIDETAKA ARIMURA
AU  - YORIHISA ORITA
AU  - HIDEKI NAKAYAMA
AU  - NATSUO OYA
TI  - Diagnostic Value of FDG-PET/CT for the Identification of Extranodal Extension in Patients With Head and Neck Squamous Cell Carcinoma
AID  - 10.21873/anticanres.14165
DP  - 2020 Apr 01
TA  - Anticancer Research
PG  - 2073--2077
VI  - 40
IP  - 4
4099  - http://ar.iiarjournals.org/content/40/4/2073.short
4100  - http://ar.iiarjournals.org/content/40/4/2073.full
SO  - Anticancer Res2020 Apr 01; 40
AB  - Background/Aim: We evaluated the diagnostic value of functional imaging with [18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) for the identification of extranodal extension (ENE) in patients with head and neck squamous cell carcinoma (HNSCC). Patients and Methods: In this study, 94 patients with HNSCC who underwent FDG-PET/CT were enrolled. We recorded the maximum standardized uptake value (SUVmax), compared the results with pathologic findings, and evaluated the diagnostic performance of using a SUVmax cut-off value for ENE. Results: Of the 566 dissected levels examined, 53 (9.4%) exhibited ENE. The mean SUVmax of LN with and without ENE were 6.67 and 1.64, respectively (p<0.001). A receiver operating characteristics (ROC) curve analysis for SUVmax showed an area under the ROC curve of 0.913. A SUVmax cut-off of 3.0 achieved diagnostic performance for identifying ENE with sensitivity, specificity, and accuracy of 81.1%, 94.3% and 93.1%, respectively. Conclusion: FDG-PET/CT findings using a SUVmax cut-off of 3.0 provides appropriate diagnostic value in identifying ENE.