TY - JOUR T1 - Diagnostic Value of FDG-PET/CT for the Identification of Extranodal Extension in Patients With Head and Neck Squamous Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 2073 LP - 2077 DO - 10.21873/anticanres.14165 VL - 40 IS - 4 AU - RYO TOYA AU - TETSUO SAITO AU - TOMOHIKO MATSUYAMA AU - YUDAI KAI AU - SHINYA SHIRAISHI AU - DAIZO MURAKAMI AU - RYOJI YOSHIDA AU - TAKAHIRO WATAKABE AU - FUMI SAKAMOTO AU - NORIKO TSUDA AU - HIDETAKA ARIMURA AU - YORIHISA ORITA AU - HIDEKI NAKAYAMA AU - NATSUO OYA Y1 - 2020/04/01 UR - http://ar.iiarjournals.org/content/40/4/2073.abstract N2 - Background/Aim: We evaluated the diagnostic value of functional imaging with [18F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) for the identification of extranodal extension (ENE) in patients with head and neck squamous cell carcinoma (HNSCC). Patients and Methods: In this study, 94 patients with HNSCC who underwent FDG-PET/CT were enrolled. We recorded the maximum standardized uptake value (SUVmax), compared the results with pathologic findings, and evaluated the diagnostic performance of using a SUVmax cut-off value for ENE. Results: Of the 566 dissected levels examined, 53 (9.4%) exhibited ENE. The mean SUVmax of LN with and without ENE were 6.67 and 1.64, respectively (p<0.001). A receiver operating characteristics (ROC) curve analysis for SUVmax showed an area under the ROC curve of 0.913. A SUVmax cut-off of 3.0 achieved diagnostic performance for identifying ENE with sensitivity, specificity, and accuracy of 81.1%, 94.3% and 93.1%, respectively. Conclusion: FDG-PET/CT findings using a SUVmax cut-off of 3.0 provides appropriate diagnostic value in identifying ENE. ER -