TY - JOUR T1 - Nucleolin and Nucleophosmin Expression in Gleason 3 and Gleason 4 Prostate Cancer With Seminal Vesicles Invasion (pT3b) JF - Anticancer Research JO - Anticancer Res SP - 1973 LP - 1979 DO - 10.21873/anticanres.14152 VL - 40 IS - 4 AU - MAREK MASIUK AU - MAGDALENA LEWANDOWSKA AU - EWA DOBAK AU - ELZBIETA URASINSKA Y1 - 2020/04/01 UR - http://ar.iiarjournals.org/content/40/4/1973.abstract N2 - Background/Aim: The aim of this study was to analyze the expression of nucleolin (NCL) and nucleophosmin (NPM) in prostate adenocarcinoma and in its loco-regional spread in the form of seminal vesicle invasion (SVI). Materials and Methods: The study was performed on tissue microarrays of 40 cases of Gleason 3+4 pT3b prostate cancers including tissue samples from SVI. The expression of NCL and NPM was detected immunohistochemically and analyzed with image analysis software. Results: The expression of NCL and NPM were higher in cancer cells within a prostate gland than in SVI. Gleason 4 pattern showed higher expression of NPM than Gleason 3 pattern cells. Conclusion: Differences in nuclear NCL and NPM expression in cancer cells between the prostate gland and SVI may indicate involvement of these proteins in loco-regional spread of adenocarcinoma of the prostate. Differences in NPM expression in Gleason 3 and Gleason 4 pattern suggest involvement of this protein in the differentiation of prostate cancer. ER -