TY - JOUR T1 - B-cell Receptor Recombinations in Lung Adenocarcinoma Exome Files Correlate With a Higher Overall Survival Rate JF - Anticancer Research JO - Anticancer Res SP - 2043 LP - 2051 DO - 10.21873/anticanres.14161 VL - 40 IS - 4 AU - YAPING N. TU AU - WEI LUE TONG AU - BLAKE M. CALLAHAN AU - BORIS I. CHOBRUTSKIY AU - GEORGE BLANCK Y1 - 2020/04/01 UR - http://ar.iiarjournals.org/content/40/4/2043.abstract N2 - Background/Aim: While there has been a rapid development in genomic data mining approaches for T-cell receptor recombinations (TcR), less emphasis has been placed on B-cell receptor (BcR) recombinations. Materials and Methods: We obtained lung cancer exome files from the cancer genome atlas (TCGA) and mined the files for TcR and BcR recombination reads. Results: There was a robust detection of BcR light chain recombination reads in lung adenocarcinoma (TCGA-LUAD) samples, and there was a correlation between the detection of light chain recombination reads and a more favorable outcome. This result was supported by analyses of the expression of B-cell markers as indicated by LUAD RNASeq files. Conclusion: BcR and TcR recombination reads recovered from LUAD WXS files, either alone or in combination with the human leukocyte antigen (HLA) type, are likely to have prognostic value. ER -