PT - JOURNAL ARTICLE AU - DIRK RADES AU - TRANG NGUYEN AU - STEFAN JANSSEN AU - STEVEN E. SCHILD TI - An Instrument to Guide Physicians when Estimating the Survival of Elderly Patients With Brain Metastasis from Gynecological Cancer AID - 10.21873/anticanres.14188 DP - 2020 Apr 01 TA - Anticancer Research PG - 2257--2260 VI - 40 IP - 4 4099 - http://ar.iiarjournals.org/content/40/4/2257.short 4100 - http://ar.iiarjournals.org/content/40/4/2257.full SO - Anticancer Res2020 Apr 01; 40 AB - Background/Aim: For treatment personalization in elderly cancer patients, survival prognoses should be considered. We developed an instrument to estimate survival of elderly patients with brain metastasis from gynecological cancer. Patients and Methods: In 15 patients, whole-brain radiotherapy regimen, tumor site, age, Karnofsky performance score (KPS), number of brain metastases, extra-cerebral metastases and interval from diagnosis of gynecological cancer until radiotherapy were retrospectively evaluated for survival. Characteristics found significant on multivariate analysis were used for the instrument. Results: In the multivariate analysis, KPS ≥70% (hazard ratio=3.71, p=0.0499) and an interval ≥28 months (hazard ratio=3.71, p=0.030) were significantly associated with better survival. Based on these characteristics, patients received 0 (n=6), 1 (n=3) or 2 points (n=6). Six-month survival rates of the groups 0-1 and 2 points were 0% and 50%, respectively (p=0.007). Conclusion: This instrument helps estimating survival in elderly patients with brain metastases from gynecological cancer and contributes to personalization of their treatment.