RT Journal Article SR Electronic T1 Impact of Bevacizumab Versus Erlotinib on Tumor Metrics in Patients With Previously Untreated Advanced Non-small Cell Lung Cancer: A Study by the Hellenic Cooperative Oncology Group JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2095 OP 2106 DO 10.21873/anticanres.14168 VO 40 IS 4 A1 GIANNIS MOUNTZIOS A1 XANTHIPPI MAVROPOULOU A1 GEORGIA-ANGELIKI KOLIOU A1 HELENA LINARDOU A1 EPAMINONTAS SAMANTAS A1 PARIS KOSMIDIS A1 GEORGE FOUNTZILAS A1 APHRODITE CHARITANDI A1 ANNA KALOGERA-FOUNTZILA YR 2020 UL http://ar.iiarjournals.org/content/40/4/2095.abstract AB Background: The mechanism of action of bevacizumab and erlotinib is quite different in the treatment of advanced non-small cell lung cancer (NSCLC). This study sought to compare the two targeted therapies in terms of sequential tumor response metrics. Patients and Methods: Parameters of radiological tumor response evaluation were assessed at baseline and periodically in 58 patients receiving either bevacizumab plus platinum-based chemotherapy (N=25) or erlotinib (N=33). Results: Bevacizumab-treated patients had lower longest diameter at best response compared to the erlotinib group (p=0.011). The longest diameter, tumor volume and density significantly decreased from baseline to best response for the entire cohort and bevacizumab-treated patients; no difference was found in the erlotinib group. Conclusion: Treatment with bevacizumab substantially improved tumor metrics between baseline and each cycle of treatment, as well as between baseline and best response, in patients with advanced NSCLC.