PT  - JOURNAL ARTICLE
AU  - ISSEI TAKEUCHI
AU  - RIKO KAWAMATA
AU  - KIMIKO MAKINO
TI  - A Rat Model of Oral Mucositis Induced by Cancer Chemotherapy for Quantitative Experiments
AID  - 10.21873/anticanres.14241
DP  - 2020 May 01
TA  - Anticancer Research
PG  - 2701--2706
VI  - 40
IP  - 5
4099  - http://ar.iiarjournals.org/content/40/5/2701.short
4100  - http://ar.iiarjournals.org/content/40/5/2701.full
SO  - Anticancer Res2020 May 01; 40
AB  - Background/Aim: Oral mucositis, which occurs frequently in the treatment of cancer, is a major problem. In this study, we aimed to develop a rat model of oral mucositis induced by cancer chemotherapy for quantitative measurement. Materials and Methods: A model animal of oral mucositis was prepared by injecting an acetic acid aqueous solution into the buccal mucosa of rats to which a 5-FU solution had been previously administered. The doses of 5-FU and acetic acid were examined, and a treatment experiment using Kenalog® was performed. Results: The optimal dose of the 5-FU solution and the optimal concentration of the acetic acid aqueous solution were 40 mg/kg and 25%, respectively. Treatment with Kenalog® confirmed that this model mimics immunocompromised oral mucositis. Conclusion: Compared with a mouse model, oral mucositis can be easily observed in this model and provides a large amount of oral mucosal tissue.