@article {TAKEUCHI2701, author = {ISSEI TAKEUCHI and RIKO KAWAMATA and KIMIKO MAKINO}, title = {A Rat Model of Oral Mucositis Induced by Cancer Chemotherapy for Quantitative Experiments}, volume = {40}, number = {5}, pages = {2701--2706}, year = {2020}, doi = {10.21873/anticanres.14241}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Oral mucositis, which occurs frequently in the treatment of cancer, is a major problem. In this study, we aimed to develop a rat model of oral mucositis induced by cancer chemotherapy for quantitative measurement. Materials and Methods: A model animal of oral mucositis was prepared by injecting an acetic acid aqueous solution into the buccal mucosa of rats to which a 5-FU solution had been previously administered. The doses of 5-FU and acetic acid were examined, and a treatment experiment using Kenalog{\textregistered} was performed. Results: The optimal dose of the 5-FU solution and the optimal concentration of the acetic acid aqueous solution were 40 mg/kg and 25\%, respectively. Treatment with Kenalog{\textregistered} confirmed that this model mimics immunocompromised oral mucositis. Conclusion: Compared with a mouse model, oral mucositis can be easily observed in this model and provides a large amount of oral mucosal tissue.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/5/2701}, eprint = {https://ar.iiarjournals.org/content/40/5/2701.full.pdf}, journal = {Anticancer Research} }