RT Journal Article
SR Electronic
T1 Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Locally Recurrent Pancreatic Cancer After Surgical Resection
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2771
OP 2775
DO 10.21873/anticanres.14249
VO 40
IS 5
A1 MÅNSSON, CHRISTOPHER
A1 NILSSON, ANDERS
A1 NYGREN, PETER
A1 KARLSON, BRITT-MARIE
YR 2020
UL http://ar.iiarjournals.org/content/40/5/2771.abstract
AB Background/Aim: Irreversible electroporation (IRE) has recently been used as an experimental treatment for cancers including locally advanced pancreatic cancer. There is very limited data on IRE in pancreatic cancer that is locally recurrent after surgical resection. The aim of this study was to evaluate the safety and efficacy of IRE in this setting. Patients and Methods: Ten patients with locally recurrent pancreatic cancer without distant metastases after surgical resection were included and treated with ultrasound-guided percutaneous IRE. Results: Two patients had severe complications, of whom one died. Median disease-free survival was 3.3 months and overall median survival after IRE and resection was 16.5 and 42.7 months, respectively. Two patients are alive 42.1 and 23.9 months after the IRE without signs of local recurrence. Conclusion: Percutaneous IRE in locally recurrent pancreatic cancer following curative resection is feasible, but should be regarded as a high-risk procedure that, at present, cannot be recommended outside of clinical trials. Further research is needed to select patients who might benefit from this treatment.